Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Austin Peay (169) | 27 | Western Kentucky (42) | 38 | Final | W | 11 |
| 2 | 2022-09-04 | Western Kentucky (42) | 49 | Hawaii (94) | 17 | Final | W | 32 |
| 3 | 2022-09-17 | Western Kentucky (65) | 30 | Indiana (12) | 33 | Final(OT) | L | -3 |
| 4 | 2022-09-24 | Florida International (133) | 0 | Western Kentucky (62) | 73 | Final | W | 73 |
| 5 | 2022-10-01 | Troy (52) | 34 | Western Kentucky (73) | 27 | Final | L | -7 |
| 6 | 2022-10-08 | Western Kentucky (85) | 28 | UTSA (55) | 31 | Final | L | -3 |
| 7 | 2022-10-15 | Western Kentucky (68) | 35 | Middle Tennessee (100) | 17 | Final | W | 18 |
| 8 | 2022-10-21 | UAB (61) | 17 | Western Kentucky (56) | 20 | Final | W | 3 |
| 9 | 2022-10-29 | North Texas (80) | 40 | Western Kentucky (71) | 13 | Final | L | -27 |
| 10 | 2022-11-05 | Western Kentucky (67) | 59 | Charlotte (147) | 7 | Final | W | 52 |
| 11 | 2022-11-12 | Rice (98) | 10 | Western Kentucky (63) | 45 | Final | W | 35 |
| 12 | 2022-11-19 | Western Kentucky (69) | 17 | Auburn (56) | 41 | Final | L | -24 |
| 13 | 2022-11-26 | Western Kentucky (66) | 32 | Florida Atlantic (96) | 31 | Final(OT) | W | 1 |
| 14 | 2022-12-21 | Western Kentucky (66) | 44 | South Alabama (28) | 23 | Final | W | 21 |