Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | USC (31) | 6 | Alabama (1) | 52 | Final | L | -46 |
| 2 | 2016-09-10 | Utah State (75) | 7 | USC (31) | 45 | Final | W | 38 |
| 3 | 2016-09-17 | USC (31) | 10 | Stanford (7) | 27 | Final | L | -17 |
| 4 | 2016-09-23 | USC (68) | 27 | Utah (29) | 31 | Final | L | -4 |
| 5 | 2016-10-01 | Arizona State (17) | 20 | USC (74) | 41 | Final | W | 21 |
| 6 | 2016-10-08 | Colorado (22) | 17 | USC (50) | 21 | Final | W | 4 |
| 7 | 2016-10-15 | USC (38) | 48 | Arizona (87) | 14 | Final | W | 34 |
| 8 | 2016-10-27 | California | 24 | USC | 45 | Final | W | 21 |
| 9 | 2016-11-05 | Oregon (71) | 20 | USC (24) | 45 | Final | W | 25 |
| 10 | 2016-11-12 | USC (22) | 26 | Washington (5) | 13 | Final | W | 13 |
| 11 | 2016-11-19 | USC (13) | 36 | UCLA (59) | 14 | Final | W | 22 |
| 12 | 2016-11-26 | Notre Dame (71) | 27 | USC (13) | 45 | Final | W | 18 |
| 13 | 2017-01-02 | USC (11) | 52 | Penn State (6) | 49 | Final | W | 3 |