Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Nebraska (73) | 28 | Northwestern (112) | 31 | Final | L | -3 |
| 2 | 2022-09-03 | North Dakota (155) | 17 | Nebraska (73) | 38 | Final | W | 21 |
| 3 | 2022-09-10 | Georgia Southern (132) | 45 | Nebraska (73) | 42 | Final | L | -3 |
| 4 | 2022-09-17 | Oklahoma (15) | 49 | Nebraska (127) | 14 | Final | L | -35 |
| 5 | 2022-10-01 | Indiana (66) | 21 | Nebraska (103) | 35 | Final | W | 14 |
| 6 | 2022-10-07 | Nebraska (94) | 14 | Rutgers (83) | 13 | Final | W | 1 |
| 7 | 2022-10-15 | Nebraska (95) | 37 | Purdue (23) | 43 | Final | L | -6 |
| 8 | 2022-10-29 | Illinois (19) | 26 | Nebraska (101) | 9 | Final | L | -17 |
| 9 | 2022-11-05 | Minnesota (42) | 20 | Nebraska (104) | 13 | Final | L | -7 |
| 10 | 2022-11-12 | Nebraska (110) | 3 | Michigan (4) | 34 | Final | L | -31 |
| 11 | 2022-11-19 | Wisconsin (54) | 15 | Nebraska (113) | 14 | Final | L | -1 |
| 12 | 2022-11-25 | Nebraska (95) | 24 | Iowa (53) | 17 | Final | W | 7 |