Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Oklahoma (9) | 23 | Houston (8) | 33 | Final | L | -10 |
| 2 | 2016-09-10 | Louisiana-Monroe | 17 | Oklahoma | 59 | Final | W | 42 |
| 3 | 2016-09-17 | Ohio State (3) | 45 | Oklahoma (9) | 24 | Final | L | -21 |
| 4 | 2016-10-01 | Oklahoma (54) | 52 | TCU (38) | 46 | Final | W | 6 |
| 5 | 2016-10-08 | Texas (64) | 40 | Oklahoma (42) | 45 | Final | W | 5 |
| 6 | 2016-10-15 | Kansas State (46) | 17 | Oklahoma (36) | 38 | Final | W | 21 |
| 7 | 2016-10-22 | Oklahoma (23) | 66 | Texas Tech (66) | 59 | Final | W | 7 |
| 8 | 2016-10-29 | Kansas (132) | 3 | Oklahoma (25) | 56 | Final | W | 53 |
| 9 | 2016-11-03 | Oklahoma (19) | 34 | Iowa State (139) | 24 | Final | W | 10 |
| 10 | 2016-11-12 | Baylor (44) | 24 | Oklahoma (19) | 45 | Final | W | 21 |
| 11 | 2016-11-19 | Oklahoma (14) | 56 | West Virginia (18) | 28 | Final | W | 28 |
| 12 | 2016-12-03 | Oklahoma State (24) | 20 | Oklahoma (10) | 38 | Final | W | 18 |
| 13 | 2017-01-02 | Auburn (14) | 19 | Oklahoma (9) | 35 | Final | W | 16 |