Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Northern Iowa | 25 | Iowa State | 20 | Final | L | -5 |
| 2 | 2016-09-10 | Iowa State (98) | 3 | Iowa (14) | 42 | Final | L | -39 |
| 3 | 2016-09-17 | Iowa State (98) | 20 | TCU (19) | 41 | Final | L | -21 |
| 4 | 2016-09-24 | San Jose State (104) | 10 | Iowa State (128) | 44 | Final | W | 34 |
| 5 | 2016-10-01 | Baylor (15) | 45 | Iowa State (121) | 42 | Final | L | -3 |
| 6 | 2016-10-08 | Iowa State (123) | 31 | Oklahoma State (45) | 38 | Final | L | -7 |
| 7 | 2016-10-15 | Iowa State (122) | 6 | Texas (75) | 27 | Final | L | -21 |
| 8 | 2016-10-29 | Kansas State (55) | 31 | Iowa State (139) | 26 | Final | L | -5 |
| 9 | 2016-11-03 | Oklahoma (19) | 34 | Iowa State (139) | 24 | Final | L | -10 |
| 10 | 2016-11-12 | Iowa State (138) | 31 | Kansas (141) | 24 | Final | W | 7 |
| 11 | 2016-11-19 | Texas Tech (72) | 10 | Iowa State (125) | 66 | Final | W | 56 |
| 12 | 2016-11-26 | West Virginia (27) | 49 | Iowa State (103) | 19 | Final | L | -30 |