Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Albany | 22 | Buffalo | 16 | Final | L | -6 |
| 2 | 2016-09-17 | Buffalo (95) | 14 | Nevada (93) | 38 | Final | L | -24 |
| 3 | 2016-09-24 | Army (14) | 20 | Buffalo (125) | 23 | Final/OT | W | 3 |
| 4 | 2016-10-01 | Buffalo (116) | 3 | Boston College (80) | 35 | Final | L | -32 |
| 5 | 2016-10-08 | Kent State (126) | 44 | Buffalo (121) | 20 | Final | L | -24 |
| 6 | 2016-10-15 | Ball State (93) | 31 | Buffalo (127) | 21 | Final | L | -10 |
| 7 | 2016-10-22 | Buffalo | 7 | Northern Illinois | 44 | Final | L | -37 |
| 8 | 2016-10-27 | Akron (68) | 20 | Buffalo (171) | 41 | Final | W | 21 |
| 9 | 2016-11-03 | Buffalo (146) | 10 | Ohio (77) | 34 | Final | L | -24 |
| 10 | 2016-11-12 | Miami (OH) (106) | 35 | Buffalo (150) | 24 | Final | L | -11 |
| 11 | 2016-11-19 | Buffalo | 0 | Western Michigan | 38 | Final | L | -38 |
| 12 | 2016-11-25 | Buffalo (156) | 19 | Bowling Green (128) | 27 | Final | L | -8 |