Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Monmouth | 15 | Middle Tennessee | 50 | Final | L | -35 |
| 2 | 2021-09-11 | Monmouth | 26 | Fordham | 23 | Final | W | 3 |
| 3 | 2021-09-18 | Monmouth | 41 | Charleston Southern | 14 | Final | W | 27 |
| 4 | 2021-09-25 | Holy Cross | 45 | Monmouth | 15 | Final | L | -30 |
| 5 | 2021-10-02 | Gardner-Webb | 17 | Monmouth | 54 | Final | W | 37 |
| 6 | 2021-10-09 | Princeton | 31 | Monmouth | 28 | Final | L | -3 |
| 7 | 2021-10-16 | Monmouth | 34 | Campbell | 17 | Final | W | 17 |
| 8 | 2021-10-30 | Monmouth | 35 | North Carolina A&T | 16 | Final | W | 19 |
| 9 | 2021-11-06 | North Alabama | 33 | Monmouth | 45 | Final | W | 12 |
| 10 | 2021-11-13 | Robert Morris | 7 | Monmouth | 44 | Final | W | 37 |
| 11 | 2021-11-20 | Monmouth | 17 | Kennesaw State | 49 | Final | L | -32 |