Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Virginia Union | 28 | Hampton | 42 | Final | W | 14 |
| 2 | 2021-09-11 | Hampton | 7 | Old Dominion | 47 | Final | L | -40 |
| 3 | 2021-09-18 | Hampton | 48 | Howard | 32 | Final | W | 16 |
| 4 | 2021-10-02 | Norfolk State | 47 | Hampton | 44 | Final(OT) | L | -3 |
| 5 | 2021-10-09 | Kennesaw State | 34 | Hampton | 15 | Final | L | -19 |
| 6 | 2021-10-16 | Hampton | 5 | Charleston Southern | 35 | Final | L | -30 |
| 7 | 2021-10-23 | North Carolina A&T | 9 | Hampton | 30 | Final | W | 21 |
| 8 | 2021-10-30 | Hampton | 35 | Robert Morris | 38 | Final | L | -3 |
| 9 | 2021-11-06 | Gardner-Webb | 21 | Hampton | 27 | Final(OT) | W | 6 |
| 10 | 2021-11-13 | Hampton | 28 | Campbell | 21 | Final | W | 7 |
| 11 | 2021-11-20 | North Alabama | 35 | Hampton | 27 | Final | L | -8 |