Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | North Dakota | 35 | Idaho State | 14 | Final | L | -21 |
| 2 | 2021-09-11 | Idaho State | 10 | Nevada | 49 | Final | L | -39 |
| 3 | 2021-09-25 | Sacramento State | 23 | Idaho State | 21 | Final | L | -2 |
| 4 | 2021-10-02 | Idaho State | 17 | Northern Arizona | 48 | Final | L | -31 |
| 5 | 2021-10-09 | UC-Davis | 17 | Idaho State | 27 | Final | W | 10 |
| 6 | 2021-10-16 | Idaho State | 10 | Portland State | 31 | Final | L | -21 |
| 7 | 2021-10-23 | Idaho State | 9 | Montana State | 27 | Final | L | -18 |
| 8 | 2021-10-30 | Weber State | 40 | Idaho State | 17 | Final | L | -23 |
| 9 | 2021-11-06 | Idaho State | 14 | BYU | 59 | Final | L | -45 |
| 10 | 2021-11-13 | Idaho State | 29 | Cal Poly | 32 | Final | L | -3 |
| 11 | 2021-11-20 | Idaho | 14 | Idaho State | 0 | Final | L | -14 |