Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Bowie State | 24 | Delaware State | 32 | Final | W | 8 |
| 2 | 2021-09-11 | Georgetown | 20 | Delaware State | 14 | Final(OT) | L | -6 |
| 3 | 2021-09-18 | Delaware State | 6 | East Tennessee State | 38 | Final | L | -32 |
| 4 | 2021-09-25 | Merrimack | 47 | Delaware State | 10 | Final | L | -37 |
| 5 | 2021-10-02 | Delaware State | 33 | Wagner | 27 | Final(OT) | W | 6 |
| 6 | 2021-10-09 | Virginia Lynchburg | 6 | Delaware State | 56 | Final | W | 50 |
| 7 | 2021-10-23 | South Carolina State | 13 | Delaware State | 7 | Final | L | -6 |
| 8 | 2021-10-30 | Howard | 23 | Delaware State | 30 | Final | W | 7 |
| 9 | 2021-11-04 | Delaware State | 14 | Morgan State | 20 | Final | L | -6 |
| 10 | 2021-11-13 | Norfolk State | 26 | Delaware State | 28 | Final | W | 2 |
| 11 | 2021-11-20 | Delaware State | 28 | North Carolina Central | 34 | Final(OT) | L | -6 |