Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Kent State | 10 | Texas A&M | 41 | Final | L | -31 |
| 2 | 2021-09-11 | Virginia Military | 10 | Kent State | 60 | Final | W | 50 |
| 3 | 2021-09-18 | Kent State | 7 | Iowa | 30 | Final | L | -23 |
| 4 | 2021-09-25 | Kent State | 16 | Maryland | 37 | Final | L | -21 |
| 5 | 2021-10-02 | Bowling Green | 20 | Kent State | 27 | Final | W | 7 |
| 6 | 2021-10-09 | Buffalo | 38 | Kent State | 48 | Final | W | 10 |
| 7 | 2021-10-16 | Kent State | 31 | Western Michigan | 64 | Final | L | -33 |
| 8 | 2021-10-23 | Kent State | 34 | Ohio | 27 | Final | W | 7 |
| 9 | 2021-11-03 | Northern Illinois | 47 | Kent State | 52 | Final | W | 5 |
| 10 | 2021-11-10 | Kent State | 30 | Central Michigan | 54 | Final | L | -24 |
| 11 | 2021-11-20 | Kent State | 38 | Akron | 0 | Final | W | 38 |
| 12 | 2021-11-27 | Miami (OH) (82) | 47 | Kent State (77) | 48 | Final(OT) | W | 1 |
| 13 | 2021-12-04 | Kent State (84) | 23 | Northern Illinois (59) | 41 | Final | L | -18 |
| 14 | 2021-12-21 | Kent State (89) | 38 | Wyoming (81) | 52 | Final | L | -14 |