Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-03 | North Carolina | 10 | Virginia Tech | 17 | Final | W | 7 |
| 2 | 2021-09-11 | Middle Tennessee | 14 | Virginia Tech | 35 | Final | W | 21 |
| 3 | 2021-09-18 | Virginia Tech | 21 | West Virginia | 27 | Final | L | -6 |
| 4 | 2021-09-25 | Richmond | 10 | Virginia Tech | 21 | Final | W | 11 |
| 5 | 2021-10-09 | Notre Dame | 32 | Virginia Tech | 29 | Final | L | -3 |
| 6 | 2021-10-16 | Pittsburgh | 28 | Virginia Tech | 7 | Final | L | -21 |
| 7 | 2021-10-23 | Syracuse | 41 | Virginia Tech | 36 | Final | L | -5 |
| 8 | 2021-10-30 | Virginia Tech | 26 | Georgia Tech | 17 | Final | W | 9 |
| 9 | 2021-11-05 | Virginia Tech | 3 | Boston College | 17 | Final | L | -14 |
| 10 | 2021-11-13 | Duke | 17 | Virginia Tech | 48 | Final | W | 31 |
| 11 | 2021-11-20 | Virginia Tech | 26 | Miami | 38 | Final | L | -12 |
| 12 | 2021-11-27 | Virginia Tech (70) | 29 | Virginia (54) | 24 | Final | W | 5 |
| 13 | 2021-12-29 | Maryland (48) | 54 | Virginia Tech (76) | 10 | Final | L | -44 |