Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | West Virginia | 24 | Maryland | 30 | Final | L | -6 |
| 2 | 2021-09-11 | Long Island | 0 | West Virginia | 66 | Final | W | 66 |
| 3 | 2021-09-18 | Virginia Tech | 21 | West Virginia | 27 | Final | W | 6 |
| 4 | 2021-09-25 | West Virginia | 13 | Oklahoma | 16 | Final | L | -3 |
| 5 | 2021-10-02 | Texas Tech | 23 | West Virginia | 20 | Final | L | -3 |
| 6 | 2021-10-09 | West Virginia | 20 | Baylor | 45 | Final | L | -25 |
| 7 | 2021-10-23 | West Virginia | 29 | TCU | 17 | Final | W | 12 |
| 8 | 2021-10-30 | Iowa State | 31 | West Virginia | 38 | Final | W | 7 |
| 9 | 2021-11-06 | Oklahoma State | 24 | West Virginia | 3 | Final | L | -21 |
| 10 | 2021-11-13 | West Virginia | 17 | Kansas State | 34 | Final | L | -17 |
| 11 | 2021-11-20 | Texas | 23 | West Virginia | 31 | Final | W | 8 |
| 12 | 2021-11-27 | West Virginia (51) | 34 | Kansas (136) | 28 | Final | W | 6 |
| 13 | 2021-12-28 | West Virginia (52) | 6 | Minnesota (26) | 18 | Final | L | -12 |