Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Tennessee-Martin | 21 | Western Kentucky | 59 | Final | L | -38 |
| 2 | 2021-09-11 | Samford | 27 | Tennessee-Martin | 33 | Final | W | 6 |
| 3 | 2021-09-18 | Tennessee-Martin | 35 | Northwestern State | 10 | Final | W | 25 |
| 4 | 2021-09-25 | Tennessee-Martin | 34 | Jacksonville State | 31 | Final | W | 3 |
| 5 | 2021-10-09 | Murray State | 24 | Tennessee-Martin | 48 | Final | W | 24 |
| 6 | 2021-10-16 | Tennessee-Martin | 28 | Eastern Illinois | 17 | Final | W | 11 |
| 7 | 2021-10-23 | Southeast Missouri State | 30 | Tennessee-Martin | 38 | Final | W | 8 |
| 8 | 2021-10-30 | Austin Peay | 16 | Tennessee-Martin | 17 | Final | W | 1 |
| 9 | 2021-11-06 | Tennessee State | 20 | Tennessee-Martin | 41 | Final | W | 21 |
| 10 | 2021-11-13 | Tennessee-Martin | 42 | Tennessee Tech | 3 | Final | W | 39 |
| 11 | 2021-11-20 | Tennessee-Martin | 14 | Southeast Missouri State | 31 | Final | L | -17 |
| 12 | 2021-11-27 | Tennessee-Martin (138) | 32 | Missouri State (132) | 31 | Final | W | 1 |
| 13 | 2021-12-04 | Tennessee-Martin (141) | 7 | Montana State (109) | 26 | Final | L | -19 |