Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-05 | Notre Dame | 41 | Florida State | 38 | Final(OT) | L | -3 |
| 2 | 2021-09-11 | Jacksonville State | 20 | Florida State | 17 | Final | L | -3 |
| 3 | 2021-09-18 | Florida State | 14 | Wake Forest | 35 | Final | L | -21 |
| 4 | 2021-09-25 | Louisville | 31 | Florida State | 23 | Final | L | -8 |
| 5 | 2021-10-02 | Syracuse | 30 | Florida State | 33 | Final | W | 3 |
| 6 | 2021-10-09 | Florida State | 35 | North Carolina | 25 | Final | W | 10 |
| 7 | 2021-10-23 | Massachusetts | 3 | Florida State | 59 | Final | W | 56 |
| 8 | 2021-10-30 | Florida State | 20 | Clemson | 30 | Final | L | -10 |
| 9 | 2021-11-06 | North Carolina State | 28 | Florida State | 14 | Final | L | -14 |
| 10 | 2021-11-13 | Miami | 28 | Florida State | 31 | Final | W | 3 |
| 11 | 2021-11-20 | Florida State | 26 | Boston College | 23 | Final | W | 3 |
| 12 | 2021-11-27 | Florida State (73) | 21 | Florida (60) | 24 | Final | L | -3 |