Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Illinois State | 14 | Iowa | 31 | Final | W | 17 |
| 2 | 2015-09-12 | Iowa (64) | 31 | Iowa State (105) | 17 | Final | W | 14 |
| 3 | 2015-09-19 | Pittsburgh | 24 | Iowa | 27 | Final | W | 3 |
| 4 | 2015-09-26 | North Texas (123) | 16 | Iowa (29) | 62 | Final | W | 46 |
| 5 | 2015-10-03 | Iowa (26) | 10 | Wisconsin (32) | 6 | Final | W | 4 |
| 6 | 2015-10-10 | Illinois (36) | 20 | Iowa (19) | 29 | Final | W | 9 |
| 7 | 2015-10-17 | Iowa (13) | 40 | Northwestern (17) | 10 | Final | W | 30 |
| 8 | 2015-10-31 | Maryland (83) | 15 | Iowa (7) | 31 | Final | W | 16 |
| 9 | 2015-11-07 | Iowa (9) | 35 | Indiana (64) | 27 | Final | W | 8 |
| 10 | 2015-11-14 | Minnesota (60) | 35 | Iowa (6) | 40 | Final | W | 5 |
| 11 | 2015-11-21 | Purdue (97) | 20 | Iowa (6) | 40 | Final | W | 20 |
| 12 | 2015-11-27 | Iowa (4) | 28 | Nebraska (49) | 20 | Final | W | 8 |
| 13 | 2015-12-05 | Michigan State (5) | 16 | Iowa (4) | 13 | Final | L | -3 |
| 14 | 2016-01-01 | Stanford (8) | 45 | Iowa (7) | 16 | Final | L | -29 |