Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Youngstown State | 37 | Pittsburgh | 45 | Final | W | 8 |
| 2 | 2015-09-12 | Pittsburgh (69) | 24 | Akron (112) | 7 | Final | W | 17 |
| 3 | 2015-09-19 | Pittsburgh | 24 | Iowa | 27 | Final | L | -3 |
| 4 | 2015-10-03 | Pittsburgh | 17 | Virginia Tech | 13 | Final | W | 4 |
| 5 | 2015-10-10 | Virginia | 19 | Pittsburgh | 26 | Final | W | 7 |
| 6 | 2015-10-17 | Pittsburgh | 31 | Georgia Tech | 28 | Final | W | 3 |
| 7 | 2015-10-24 | Pittsburgh | 23 | Syracuse | 20 | Final | W | 3 |
| 8 | 2015-10-29 | North Carolina | 26 | Pittsburgh | 19 | Final | L | -7 |
| 9 | 2015-11-07 | Notre Dame | 42 | Pittsburgh | 30 | Final | L | -12 |
| 10 | 2015-11-14 | Pittsburgh | 31 | Duke | 13 | Final | W | 18 |
| 11 | 2015-11-21 | Louisville | 34 | Pittsburgh | 45 | Final | W | 11 |
| 12 | 2015-11-27 | Miami | 29 | Pittsburgh | 24 | Final | L | -5 |
| 13 | 2015-12-28 | Pittsburgh | 28 | Navy | 44 | Final | L | -16 |