Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-06 | Purdue (95) | 31 | Marshall (29) | 41 | Final | L | -10 |
| 2 | 2015-09-12 | Indiana State | 14 | Purdue | 38 | Final | W | 24 |
| 3 | 2015-09-19 | Virginia Tech (76) | 51 | Purdue (102) | 24 | Final | L | -27 |
| 4 | 2015-09-26 | Bowling Green (75) | 35 | Purdue (112) | 28 | Final | L | -7 |
| 5 | 2015-10-03 | Purdue (117) | 21 | Michigan State (14) | 24 | Final | L | -3 |
| 6 | 2015-10-10 | Minnesota (46) | 41 | Purdue (113) | 13 | Final | L | -28 |
| 7 | 2015-10-17 | Purdue (109) | 7 | Wisconsin (32) | 24 | Final | L | -17 |
| 8 | 2015-10-31 | Nebraska (59) | 45 | Purdue (103) | 55 | Final | W | 10 |
| 9 | 2015-11-07 | Illinois (66) | 48 | Purdue (93) | 14 | Final | L | -34 |
| 10 | 2015-11-14 | Purdue (101) | 14 | Northwestern (20) | 21 | Final | L | -7 |
| 11 | 2015-11-21 | Purdue (97) | 20 | Iowa (6) | 40 | Final | L | -20 |
| 12 | 2015-11-28 | Indiana (60) | 54 | Purdue (98) | 36 | Final | L | -18 |