Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Northern Iowa | 7 | Iowa State | 31 | Final | W | 24 |
| 2 | 2015-09-12 | Iowa (64) | 31 | Iowa State (105) | 17 | Final | L | -14 |
| 3 | 2015-09-19 | Iowa State (94) | 23 | Toledo (35) | 30 | Final/2OT | L | -7 |
| 4 | 2015-10-03 | Kansas (127) | 13 | Iowa State (86) | 38 | Final | W | 25 |
| 5 | 2015-10-10 | Iowa State (83) | 31 | Texas Tech (55) | 66 | Final | L | -35 |
| 6 | 2015-10-17 | TCU (6) | 45 | Iowa State (96) | 21 | Final | L | -24 |
| 7 | 2015-10-24 | Iowa State (94) | 27 | Baylor (5) | 45 | Final | L | -18 |
| 8 | 2015-10-31 | Texas (49) | 0 | Iowa State (96) | 24 | Final | W | 24 |
| 9 | 2015-11-07 | Iowa State (90) | 16 | Oklahoma (19) | 52 | Final | L | -36 |
| 10 | 2015-11-14 | Oklahoma State (5) | 35 | Iowa State (96) | 31 | Final | L | -4 |
| 11 | 2015-11-21 | Iowa State (96) | 35 | Kansas State (76) | 38 | Final | L | -3 |
| 12 | 2015-11-28 | Iowa State (97) | 6 | West Virginia (31) | 30 | Final | L | -24 |