Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-04 | Michigan State (9) | 37 | Western Michigan (68) | 24 | Final | W | 13 |
| 2 | 2015-09-12 | Oregon (3) | 28 | Michigan State (9) | 31 | Final | W | 3 |
| 3 | 2015-09-19 | Air Force (26) | 21 | Michigan State (29) | 35 | Final | W | 14 |
| 4 | 2015-09-26 | Central Michigan | 10 | Michigan State | 30 | Final | W | 20 |
| 5 | 2015-10-03 | Purdue (117) | 21 | Michigan State (14) | 24 | Final | W | 3 |
| 6 | 2015-10-10 | Michigan State (15) | 31 | Rutgers (95) | 24 | Final | W | 7 |
| 7 | 2015-10-17 | Michigan State (19) | 27 | Michigan (3) | 23 | Final | W | 4 |
| 8 | 2015-10-24 | Indiana (54) | 26 | Michigan State (6) | 52 | Final | W | 26 |
| 9 | 2015-11-07 | Michigan State (5) | 38 | Nebraska (70) | 39 | Final | L | -1 |
| 10 | 2015-11-14 | Maryland (82) | 7 | Michigan State (16) | 24 | Final | W | 17 |
| 11 | 2015-11-21 | Michigan State (16) | 17 | Ohio State (3) | 14 | Final | W | 3 |
| 12 | 2015-11-28 | Penn State (43) | 16 | Michigan State (7) | 55 | Final | W | 39 |
| 13 | 2015-12-05 | Michigan State (5) | 16 | Iowa (4) | 13 | Final | W | 3 |
| 14 | 2015-12-31 | Michigan State (3) | 0 | Alabama (2) | 38 | Final | L | -38 |