Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Florida Atlantic (99) | 38 | Ohio (141) | 41 | Final | W | 3 |
| 2 | 2022-09-10 | Ohio (141) | 10 | Penn State (31) | 46 | Final | L | -36 |
| 3 | 2022-09-17 | Ohio (83) | 10 | Iowa State (19) | 43 | Final | L | -33 |
| 4 | 2022-09-24 | Fordham (151) | 52 | Ohio (87) | 59 | Final | W | 7 |
| 5 | 2022-10-01 | Ohio (107) | 24 | Kent State (83) | 31 | Final(OT) | L | -7 |
| 6 | 2022-10-08 | Akron (146) | 34 | Ohio (103) | 55 | Final | W | 21 |
| 7 | 2022-10-15 | Ohio (96) | 33 | Western Michigan (128) | 14 | Final | W | 19 |
| 8 | 2022-10-22 | Northern Illinois (129) | 17 | Ohio (87) | 24 | Final | W | 7 |
| 9 | 2022-11-01 | Buffalo (81) | 24 | Ohio (78) | 45 | Final | W | 21 |
| 10 | 2022-11-08 | Ohio (72) | 37 | Miami (OH) (121) | 21 | Final | W | 16 |
| 11 | 2022-11-15 | Ohio (70) | 32 | Ball State (106) | 18 | Final | W | 14 |
| 12 | 2022-11-22 | Bowling Green (107) | 14 | Ohio (65) | 38 | Final | W | 24 |
| 13 | 2022-12-03 | Toledo (74) | 17 | Ohio (70) | 7 | Final | L | -10 |
| 14 | 2022-12-30 | Ohio (70) | 30 | Wyoming (88) | 27 | Final(OT) | W | 3 |