Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Penn State (31) | 35 | Purdue (18) | 31 | Final | L | -4 |
| 2 | 2022-09-10 | Indiana State (174) | 0 | Purdue (18) | 56 | Final | W | 56 |
| 3 | 2022-09-17 | Purdue (79) | 29 | Syracuse (10) | 32 | Final | L | -3 |
| 4 | 2022-09-24 | Florida Atlantic (108) | 26 | Purdue (63) | 28 | Final | W | 2 |
| 5 | 2022-10-01 | Purdue (38) | 20 | Minnesota (35) | 10 | Final | W | 10 |
| 6 | 2022-10-08 | Purdue (25) | 31 | Maryland (33) | 29 | Final | W | 2 |
| 7 | 2022-10-15 | Nebraska (95) | 37 | Purdue (23) | 43 | Final | W | 6 |
| 8 | 2022-10-22 | Purdue (35) | 24 | Wisconsin (57) | 35 | Final | L | -11 |
| 9 | 2022-11-05 | Iowa (57) | 24 | Purdue (51) | 3 | Final | L | -21 |
| 10 | 2022-11-12 | Purdue (41) | 31 | Illinois (35) | 24 | Final | W | 7 |
| 11 | 2022-11-19 | Northwestern (137) | 9 | Purdue (45) | 17 | Final | W | 8 |
| 12 | 2022-11-26 | Purdue (41) | 30 | Indiana (86) | 16 | Final | W | 14 |
| 13 | 2022-12-03 | Purdue (43) | 22 | Michigan (2) | 43 | Final | L | -21 |
| 14 | 2023-01-02 | LSU (15) | 63 | Purdue (43) | 7 | Final | L | -56 |