Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-03 | Duke | 28 | Charlotte | 31 | Final | W | 3 |
| 2 | 2021-09-11 | Gardner-Webb | 10 | Charlotte | 38 | Final | W | 28 |
| 3 | 2021-09-18 | Charlotte | 7 | Georgia State | 20 | Final | L | -13 |
| 4 | 2021-09-24 | Middle Tennessee | 39 | Charlotte | 42 | Final | W | 3 |
| 5 | 2021-10-02 | Charlotte | 14 | Illinois | 24 | Final | L | -10 |
| 6 | 2021-10-08 | Charlotte | 45 | Florida International | 33 | Final | W | 12 |
| 7 | 2021-10-21 | Florida Atlantic | 38 | Charlotte | 9 | Final | L | -29 |
| 8 | 2021-10-30 | Charlotte | 13 | Western Kentucky | 45 | Final | L | -32 |
| 9 | 2021-11-06 | Rice | 24 | Charlotte | 31 | Final(OT) | W | 7 |
| 10 | 2021-11-13 | Charlotte | 32 | Louisiana Tech | 42 | Final | L | -10 |
| 11 | 2021-11-20 | Marshall | 49 | Charlotte | 28 | Final | L | -21 |
| 12 | 2021-11-27 | Charlotte (122) | 34 | Old Dominion (94) | 56 | Final | L | -22 |