Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-08-28 | Nebraska | 22 | Illinois | 30 | Final | L | -8 |
| 2 | 2021-09-04 | Fordham | 7 | Nebraska | 52 | Final | W | 45 |
| 3 | 2021-09-11 | Buffalo | 3 | Nebraska | 28 | Final | W | 25 |
| 4 | 2021-09-18 | Nebraska | 16 | Oklahoma | 23 | Final | L | -7 |
| 5 | 2021-09-25 | Nebraska | 20 | Michigan State | 23 | Final(OT) | L | -3 |
| 6 | 2021-10-02 | Northwestern | 7 | Nebraska | 56 | Final | W | 49 |
| 7 | 2021-10-09 | Michigan | 32 | Nebraska | 29 | Final | L | -3 |
| 8 | 2021-10-16 | Nebraska | 23 | Minnesota | 30 | Final | L | -7 |
| 9 | 2021-10-30 | Purdue | 28 | Nebraska | 23 | Final | L | -5 |
| 10 | 2021-11-06 | Ohio State | 26 | Nebraska | 17 | Final | L | -9 |
| 11 | 2021-11-20 | Nebraska | 28 | Wisconsin | 35 | Final | L | -7 |
| 12 | 2021-11-26 | Iowa (12) | 28 | Nebraska (75) | 21 | Final | L | -7 |