Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | UTSA | 37 | Illinois | 30 | Final | W | 7 |
| 2 | 2021-09-11 | Lamar | 0 | UTSA | 54 | Final | W | 54 |
| 3 | 2021-09-18 | Middle Tennessee | 13 | UTSA | 27 | Final | W | 14 |
| 4 | 2021-09-25 | UTSA | 31 | Memphis | 28 | Final | W | 3 |
| 5 | 2021-10-02 | UNLV | 17 | UTSA | 24 | Final | W | 7 |
| 6 | 2021-10-06 | UTSA | 0 | Western Kentucky | 0 | Cancelled | - | - |
| 7 | 2021-10-09 | UTSA | 52 | Western Kentucky | 46 | Final | W | 6 |
| 8 | 2021-10-16 | Rice | 0 | UTSA | 45 | Final | W | 45 |
| 9 | 2021-10-23 | UTSA | 45 | Louisiana Tech | 16 | Final | W | 29 |
| 10 | 2021-11-06 | UTSA | 44 | UTEP | 23 | Final | W | 21 |
| 11 | 2021-11-13 | Southern Miss | 17 | UTSA | 27 | Final | W | 10 |
| 12 | 2021-11-20 | UAB | 31 | UTSA | 34 | Final | W | 3 |
| 13 | 2021-11-27 | UTSA (22) | 23 | North Texas (90) | 45 | Final | L | -22 |
| 14 | 2021-12-03 | Western Kentucky (47) | 41 | UTSA (18) | 49 | Final | W | 8 |
| 15 | 2021-12-21 | UTSA (23) | 24 | San Diego State (19) | 38 | Final | L | -14 |