Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | BYU (25) | 50 | South Florida (131) | 21 | Final | L | -29 |
| 2 | 2022-09-10 | Howard (243) | 20 | South Florida (131) | 42 | Final | W | 22 |
| 3 | 2022-09-17 | South Florida (105) | 28 | Florida (41) | 31 | Final | L | -3 |
| 4 | 2022-09-24 | South Florida (111) | 3 | Louisville (43) | 41 | Final | L | -38 |
| 5 | 2022-10-01 | East Carolina (71) | 48 | South Florida (132) | 28 | Final | L | -20 |
| 6 | 2022-10-08 | South Florida (127) | 24 | Cincinnati (36) | 28 | Final | L | -4 |
| 7 | 2022-10-15 | Tulane (23) | 45 | South Florida (127) | 31 | Final | L | -14 |
| 8 | 2022-10-29 | South Florida (132) | 27 | Houston (50) | 42 | Final | L | -15 |
| 9 | 2022-11-05 | South Florida (140) | 28 | Temple (131) | 54 | Final | L | -26 |
| 10 | 2022-11-12 | SMU (48) | 41 | South Florida (145) | 23 | Final | L | -18 |
| 11 | 2022-11-18 | South Florida (152) | 42 | Tulsa (110) | 48 | Final | L | -6 |
| 12 | 2022-11-26 | Central Florida (23) | 46 | South Florida (147) | 39 | Final | L | -7 |