Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Duquesne | 3 | TCU | 45 | Final | W | 42 |
| 2 | 2021-09-11 | California | 32 | TCU | 34 | Final | W | 2 |
| 3 | 2021-09-25 | SMU | 42 | TCU | 34 | Final | L | -8 |
| 4 | 2021-10-02 | Texas | 32 | TCU | 27 | Final | L | -5 |
| 5 | 2021-10-09 | TCU | 52 | Texas Tech | 31 | Final | W | 21 |
| 6 | 2021-10-16 | TCU | 31 | Oklahoma | 52 | Final | L | -21 |
| 7 | 2021-10-23 | West Virginia | 29 | TCU | 17 | Final | L | -12 |
| 8 | 2021-10-30 | TCU | 12 | Kansas State | 31 | Final | L | -19 |
| 9 | 2021-11-06 | Baylor | 28 | TCU | 30 | Final | W | 2 |
| 10 | 2021-11-13 | TCU | 16 | Oklahoma State | 63 | Final | L | -47 |
| 11 | 2021-11-13 | TCU | 17 | Oklahoma State | 63 | Final | L | -46 |
| 12 | 2021-11-20 | Kansas | 28 | TCU | 31 | Final | W | 3 |
| 13 | 2021-11-26 | TCU (81) | 14 | Iowa State (35) | 48 | Final | L | -34 |