Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Eastern Kentucky (156) | 34 | Eastern Michigan (87) | 42 | Final | L | -8 |
| 2 | 2022-09-10 | Eastern Kentucky (156) | 59 | Bowling Green (128) | 57 | Final(7OT) | W | 2 |
| 3 | 2022-09-17 | Charleston Southern (235) | 17 | Eastern Kentucky (132) | 40 | Final | W | 23 |
| 4 | 2022-09-24 | Eastern Kentucky (149) | 20 | Austin Peay (138) | 31 | Final | L | -11 |
| 5 | 2022-10-01 | Southern Utah (175) | 28 | Eastern Kentucky (145) | 35 | Final | W | 7 |
| 6 | 2022-10-15 | Sam Houston State (162) | 25 | Eastern Kentucky (166) | 17 | Final | L | -8 |
| 7 | 2022-10-22 | North Alabama (246) | 53 | Eastern Kentucky (168) | 56 | Final | W | 3 |
| 8 | 2022-10-29 | Eastern Kentucky (158) | 28 | Southeast Missouri State (146) | 23 | Final | W | 5 |
| 9 | 2022-11-05 | Central Arkansas (192) | 14 | Eastern Kentucky (148) | 42 | Final | W | 28 |
| 10 | 2022-11-12 | Eastern Kentucky (159) | 17 | Jacksonville State (136) | 42 | Final | L | -25 |
| 11 | 2022-11-19 | Kennesaw State (188) | 38 | Eastern Kentucky (158) | 45 | Final | W | 7 |
| 12 | 2022-11-26 | Gardner-Webb (159) | 52 | Eastern Kentucky (162) | 41 | Final | L | -11 |