Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Presbyterian (256) | 0 | Austin Peay (169) | 63 | Final | L | -63 |
| 2 | 2022-09-10 | Virginia Lynchburg | 13 | Presbyterian (256) | 21 | Final | W | 8 |
| 3 | 2022-09-17 | Presbyterian (255) | 21 | Western Carolina (155) | 77 | Final | L | -56 |
| 4 | 2022-09-24 | Davidson (185) | 56 | Presbyterian (258) | 24 | Final | L | -32 |
| 5 | 2022-10-01 | Presbyterian (257) | 10 | Morehead State (238) | 14 | Final | L | -4 |
| 6 | 2022-10-08 | Valparaiso (221) | 41 | Presbyterian (258) | 21 | Final | L | -20 |
| 7 | 2022-10-15 | Presbyterian (258) | 0 | San Diego (246) | 0 | Final | - | - |
| 8 | 2022-10-22 | St. Thomas (192) | 46 | Presbyterian (259) | 17 | Final | L | -29 |
| 9 | 2022-10-29 | Presbyterian (260) | 7 | Marist (243) | 37 | Final | L | -30 |
| 10 | 2022-11-05 | Dayton (203) | 52 | Presbyterian (261) | 28 | Final | L | -24 |
| 11 | 2022-11-19 | Presbyterian (261) | 21 | Stetson (252) | 42 | Final | L | -21 |