Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Sam Houston State (120) | 67 | 97 | SMU (45) | Final | W | 30 |
| 2 | 2020-11-30 | Texas A&M-Corpus Christi (208) | 54 | 91 | SMU (45) | Final | W | 37 |
| 3 | 2020-12-02 | Houston Christian (305) | 75 | 102 | SMU (45) | Final | W | 27 |
| 4 | 2020-12-02 | Houston Baptist (336) | 75 | 102 | SMU (81) | Final | W | 27 |
| 5 | 2020-12-05 | SMU (45) | 66 | 64 | Dayton (66) | Final | W | 2 |
| 6 | 2020-12-08 | Vanderbilt (17) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 7 | 2020-12-08 | Vanderbilt (109) | SMU (21) | Cancelled | - | - | ||
| 8 | 2020-12-16 | East Carolina (252) | 55 | 70 | SMU (45) | Final | W | 15 |
| 9 | 2020-12-30 | SMU (45) | 79 | 71 | Temple (169) | Final | W | 8 |
| 10 | 2021-01-03 | Houston (5) | 74 | 60 | SMU (45) | Final | L | -14 |
| 11 | 2021-01-07 | Cincinnati (54) | 76 | 69 | SMU (45) | Final | L | -7 |
| 12 | 2021-01-11 | Temple (169) | 68 | 79 | SMU (45) | Final | W | 11 |
| 13 | 2021-01-14 | SMU (45) | 0 | 0 | Memphis (136) | Postponed | - | - |
| 14 | 2021-01-17 | Wichita State (76) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 15 | 2021-01-20 | SMU (45) | 0 | 0 | Tulane (167) | Cancelled | - | - |
| 16 | 2021-01-23 | SMU (45) | 78 | 65 | Central Florida (43) | Final | W | 13 |
| 17 | 2021-01-26 | SMU (45) | 72 | 76 | Memphis (136) | Final | L | -4 |
| 18 | 2021-01-28 | Memphis (136) | 65 | 67 | SMU (45) | Final | W | 2 |
| 19 | 2021-01-31 | SMU (45) | 48 | 70 | Houston (5) | Final | L | -22 |
| 20 | 2021-02-03 | SMU (45) | 65 | 63 | Tulsa (55) | Final | W | 2 |
| 21 | 2021-02-06 | South Florida (52) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 22 | 2021-02-08 | SMU (45) | 71 | 56 | East Carolina (252) | Final | W | 15 |
| 23 | 2021-02-13 | SMU | 0 | 0 | Tulsa | Cancelled | - | - |
| 24 | 2021-02-14 | Wichita State (76) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 25 | 2021-02-17 | Tulane (167) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 26 | 2021-02-20 | South Florida (52) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 27 | 2021-02-23 | Central Florida (43) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 28 | 2021-02-25 | SMU (46) | 0 | 0 | Wichita State (49) | Cancelled | - | - |
| 29 | 2021-02-28 | Wichita State (49) | 0 | 0 | SMU (44) | Cancelled | - | - |
| 30 | 2021-02-28 | SMU (45) | 0 | 0 | Wichita State (76) | Postponed | - | - |
| 31 | 2021-03-04 | SMU | 0 | 0 | Cincinnati | Cancelled | - | - |
| 32 | 2021-03-07 | Tulsa (55) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 33 | 2021-03-12 | Cincinnati (54) | 74 | 71 | SMU (45) | Final | L | -3 |
| 34 | 2021-03-18 | SMU (54) | 84 | 85 | Boise State (51) | Final | L | -1 |