Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-26 | La Salle (237) | 65 | 82 | St. John's (12) | Final | L | -17 |
| 2 | 2020-11-27 | Saint Peter's (200) | 62 | 51 | La Salle (237) | Final | L | -11 |
| 3 | 2020-12-02 | La Salle (237) | 0 | 0 | Howard (211) | Cancelled | - | - |
| 4 | 2020-12-06 | La Salle (332) | 0 | 0 | Temple (219) | Cancelled | - | - |
| 5 | 2020-12-06 | La Salle (237) | 59 | 63 | Army (339) | Final | L | -4 |
| 6 | 2020-12-08 | Lincoln (PA) | 62 | 80 | La Salle (237) | Final | W | 18 |
| 7 | 2020-12-09 | Massachusetts (182) | 0 | 0 | La Salle (237) | Postponed | - | - |
| 8 | 2020-12-12 | La Salle (237) | 58 | 48 | Drexel (215) | Final | W | 10 |
| 9 | 2020-12-16 | La Salle (253) | 0 | 0 | Towson (333) | Cancelled | - | - |
| 10 | 2020-12-16 | Massachusetts (182) | 85 | 66 | La Salle (237) | Final | L | -19 |
| 11 | 2020-12-19 | Delaware (287) | 61 | 71 | La Salle (237) | Final | W | 10 |
| 12 | 2020-12-22 | La Salle (237) | 71 | 84 | Maryland (114) | Final | L | -13 |
| 13 | 2020-12-30 | La Salle (237) | 67 | 65 | Dayton (66) | Final | W | 2 |
| 14 | 2021-01-02 | Fordham (183) | 52 | 89 | La Salle (237) | Final | W | 37 |
| 15 | 2021-01-06 | Saint Louis (31) | 0 | 0 | La Salle (237) | Postponed | - | - |
| 16 | 2021-01-09 | La Salle (237) | 67 | 83 | Massachusetts (182) | Final | L | -16 |
| 17 | 2021-01-13 | La Salle (237) | 42 | 75 | George Mason (86) | Final | L | -33 |
| 18 | 2021-01-16 | Davidson (111) | 77 | 53 | La Salle (237) | Final | L | -24 |
| 19 | 2021-01-18 | Saint Joseph's (99) | 83 | 90 | La Salle (237) | Final | W | 7 |
| 20 | 2021-01-23 | La Salle (237) | 84 | 78 | Richmond (166) | Final | W | 6 |
| 21 | 2021-01-27 | Rhode Island (145) | 73 | 60 | La Salle (237) | Final | L | -13 |
| 22 | 2021-01-30 | La Salle (237) | 62 | 73 | Virginia Commonwealth (38) | Final | L | -11 |
| 23 | 2021-02-03 | Saint Louis (31) | 75 | 82 | La Salle (237) | Final | W | 7 |
| 24 | 2021-02-06 | La Salle (193) | 0 | 0 | Saint Joseph's (305) | Cancelled | - | - |
| 25 | 2021-02-06 | La Salle (237) | 68 | 76 | Fordham (183) | Final | L | -8 |
| 26 | 2021-02-09 | La Salle (237) | 73 | 86 | St. Bonaventure (146) | Final | L | -13 |
| 27 | 2021-02-13 | George Washington (104) | 0 | 0 | La Salle (237) | Cancelled | - | - |
| 28 | 2021-02-16 | La Salle (237) | 57 | 78 | Saint Louis (31) | Final | L | -21 |
| 29 | 2021-02-20 | Richmond (61) | 0 | 0 | La Salle (193) | Cancelled | - | - |
| 30 | 2021-02-20 | La Salle (237) | 82 | 91 | Saint Joseph's (99) | Final/OT | L | -9 |
| 31 | 2021-02-24 | Duquesne (121) | 65 | 85 | La Salle (237) | Final | W | 20 |
| 32 | 2021-02-27 | La Salle (237) | 54 | 89 | George Mason (86) | Final | L | -35 |
| 33 | 2021-03-03 | Saint Joseph's (99) | 72 | 66 | La Salle (237) | Final | L | -6 |