Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Drake (217) | 80 | 70 | Kansas State (96) | Final | W | 10 |
| 2 | 2020-11-27 | South Dakota (275) | 53 | 69 | Drake (217) | Final | W | 16 |
| 3 | 2020-11-27 | South Dakota (184) | 54 | 69 | Drake (149) | Final | W | 15 |
| 4 | 2020-12-03 | Nebraska-Omaha (272) | 66 | 87 | Drake (217) | Final | W | 21 |
| 5 | 2020-12-06 | St. Ambrose | 53 | 97 | Drake (217) | Final | W | 44 |
| 6 | 2020-12-09 | McKendree | 66 | 90 | Drake (217) | Final | W | 24 |
| 7 | 2020-12-13 | Air Force (347) | 53 | 81 | Drake (217) | Final | W | 28 |
| 8 | 2020-12-16 | Drake (217) | 0 | 0 | South Dakota (275) | Postponed | - | - |
| 9 | 2020-12-18 | Drake (217) | 75 | 57 | South Dakota (275) | Final | W | 18 |
| 10 | 2020-12-20 | Chicago State (351) | 67 | 111 | Drake (217) | Final | W | 44 |
| 11 | 2020-12-22 | North Dakota (251) | 55 | 88 | Drake (217) | Final | W | 33 |
| 12 | 2020-12-27 | Drake (217) | 81 | 63 | Indiana State (243) | Final | W | 18 |
| 13 | 2020-12-28 | Drake (217) | 73 | 66 | Indiana State (243) | Final | W | 7 |
| 14 | 2020-12-30 | Drake (28) | Loyola-Chicago (99) | Cancelled | - | - | ||
| 15 | 2021-01-02 | Indiana State (168) | Drake (28) | Cancelled | - | - | ||
| 16 | 2021-01-03 | Southern Illinois (150) | 55 | 73 | Drake (217) | Final | W | 18 |
| 17 | 2021-01-04 | Southern Illinois (150) | 55 | 86 | Drake (217) | Final | W | 31 |
| 18 | 2021-01-10 | Loyola-Chicago (76) | 0 | 0 | Drake (20) | Cancelled | - | - |
| 19 | 2021-01-11 | Loyola-Chicago (112) | 0 | 0 | Drake (13) | Cancelled | - | - |
| 20 | 2021-01-13 | Bradley | Drake | Cancelled | - | - | ||
| 21 | 2021-01-16 | Drake | Indiana State | Cancelled | - | - | ||
| 22 | 2021-01-17 | Drake (217) | 0 | 0 | Missouri State (224) | Postponed | - | - |
| 23 | 2021-01-18 | Drake (11) | 0 | 0 | Missouri State (71) | Cancelled | - | - |
| 24 | 2021-01-20 | Drake | Southern Illinois | Cancelled | - | - | ||
| 25 | 2021-01-21 | Drake (11) | 0 | 0 | Northern Iowa (232) | Cancelled | - | - |
| 26 | 2021-01-23 | Evansville | Drake | Cancelled | - | - | ||
| 27 | 2021-01-26 | Drake (217) | 68 | 61 | Missouri State (224) | Final | W | 7 |
| 28 | 2021-01-27 | Drake | Valparaiso | Cancelled | - | - | ||
| 29 | 2021-01-27 | Drake (217) | 78 | 73 | Missouri State (224) | Final | W | 5 |
| 30 | 2021-01-30 | Northern Iowa | Drake | Cancelled | - | - | ||
| 31 | 2021-01-31 | Illinois State (94) | 76 | 78 | Drake (217) | Final/OT | W | 2 |
| 32 | 2021-02-01 | Illinois State (94) | 60 | 95 | Drake (217) | Final | W | 35 |
| 33 | 2021-02-06 | Drake | Missouri State | Cancelled | - | - | ||
| 34 | 2021-02-06 | Drake (217) | 80 | 77 | Valparaiso (156) | Final | W | 3 |
| 35 | 2021-02-07 | Drake (217) | 57 | 74 | Valparaiso (156) | Final | L | -17 |
| 36 | 2021-02-10 | Valparaiso | Drake | Cancelled | - | - | ||
| 37 | 2021-02-10 | Northern Iowa (89) | 59 | 80 | Drake (217) | Final | W | 21 |
| 38 | 2021-02-13 | Loyola-Chicago (263) | 81 | 54 | Drake (217) | Final | L | -27 |
| 39 | 2021-02-14 | Drake | Northern Iowa | Cancelled | - | - | ||
| 40 | 2021-02-14 | Loyola-Chicago (263) | 50 | 51 | Drake (217) | Final/OT | W | 1 |
| 41 | 2021-02-17 | Drake | Bradley | Cancelled | - | - | ||
| 42 | 2021-02-17 | Drake (217) | 77 | 69 | Northern Iowa (89) | Final | W | 8 |
| 43 | 2021-02-21 | Southern Illinois | Drake | Cancelled | - | - | ||
| 44 | 2021-02-21 | Evansville (302) | 71 | 85 | Drake (217) | Final | W | 14 |
| 45 | 2021-02-22 | Evansville (302) | 63 | 74 | Drake (217) | Final | W | 11 |
| 46 | 2021-02-24 | Loyola-Chicago | Drake | Cancelled | - | - | ||
| 47 | 2021-02-26 | Drake (217) | 80 | 71 | Bradley (113) | Final | W | 9 |
| 48 | 2021-02-27 | Drake | Illinois State | Cancelled | - | - | ||
| 49 | 2021-02-27 | Drake (217) | 61 | 67 | Bradley (113) | Final | L | -6 |
| 50 | 2021-03-05 | Northern Iowa (89) | 0 | 0 | Drake (217) | Cancelled | - | - |
| 51 | 2021-03-06 | Missouri State (224) | 69 | 71 | Drake (217) | Final | W | 2 |
| 52 | 2021-03-07 | Drake (217) | 65 | 75 | Loyola-Chicago (263) | Final | L | -10 |
| 53 | 2021-03-18 | Drake (43) | 53 | 52 | Wichita State (47) | Final | W | 1 |
| 54 | 2021-03-20 | Drake (43) | 56 | 72 | USC (16) | Final | L | -16 |