Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-12-05 | Lewis | 48 | 76 | Loyola-Chicago (263) | Final | W | 28 |
| 2 | 2020-12-09 | Chicago State (351) | 51 | 88 | Loyola-Chicago (263) | Final | W | 37 |
| 3 | 2020-12-13 | Loyola-Chicago (263) | 77 | 66 | Illinois-Chicago (139) | Final | W | 11 |
| 4 | 2020-12-15 | Loyola-Chicago (263) | 63 | 77 | Wisconsin (24) | Final | L | -14 |
| 5 | 2020-12-18 | Richmond (166) | 75 | 73 | Loyola-Chicago (263) | Final | L | -2 |
| 6 | 2020-12-18 | Loyola-Chicago (78) | 73 | 75 | Richmond (65) | Final | L | -2 |
| 7 | 2020-12-22 | St. Francis (IL) | 55 | 92 | Loyola-Chicago (263) | Final | W | 37 |
| 8 | 2020-12-27 | Illinois State (94) | 60 | 90 | Loyola-Chicago (263) | Final | W | 30 |
| 9 | 2020-12-28 | Illinois State (94) | 55 | 86 | Loyola-Chicago (263) | Final | W | 31 |
| 10 | 2020-12-30 | Drake (28) | Loyola-Chicago (99) | Cancelled | - | - | ||
| 11 | 2021-01-02 | Loyola-Chicago (99) | Valparaiso (277) | Cancelled | - | - | ||
| 12 | 2021-01-02 | North Texas (125) | 49 | 57 | Loyola-Chicago (263) | Final | W | 8 |
| 13 | 2021-01-03 | Loyola-Chicago (263) | 0 | 0 | Bradley (113) | Postponed | - | - |
| 14 | 2021-01-04 | Loyola-Chicago (99) | 0 | 0 | Bradley (89) | Cancelled | - | - |
| 15 | 2021-01-07 | Loyola-Chicago (76) | Missouri State (92) | Cancelled | - | - | ||
| 16 | 2021-01-10 | Loyola-Chicago (76) | 0 | 0 | Drake (20) | Cancelled | - | - |
| 17 | 2021-01-10 | Loyola-Chicago (263) | 71 | 76 | Indiana State (243) | Final | L | -5 |
| 18 | 2021-01-11 | Loyola-Chicago (112) | 0 | 0 | Drake (13) | Cancelled | - | - |
| 19 | 2021-01-11 | Loyola-Chicago (263) | 58 | 48 | Indiana State (243) | Final | W | 10 |
| 20 | 2021-01-13 | Illinois State | Loyola-Chicago | Cancelled | - | - | ||
| 21 | 2021-01-16 | Loyola-Chicago | Evansville | Cancelled | - | - | ||
| 22 | 2021-01-16 | Northern Iowa (89) | 57 | 72 | Loyola-Chicago (263) | Final | W | 15 |
| 23 | 2021-01-17 | Northern Iowa (89) | 46 | 88 | Loyola-Chicago (263) | Final | W | 42 |
| 24 | 2021-01-19 | Missouri State | Loyola-Chicago | Cancelled | - | - | ||
| 25 | 2021-01-20 | Loyola-Chicago (263) | 75 | 39 | Valparaiso (156) | Final | W | 36 |
| 26 | 2021-01-23 | Loyola-Chicago | Indiana State | Cancelled | - | - | ||
| 27 | 2021-01-24 | Loyola-Chicago (263) | 69 | 56 | Bradley (113) | Final | W | 13 |
| 28 | 2021-01-25 | Loyola-Chicago (263) | 65 | 58 | Bradley (113) | Final | W | 7 |
| 29 | 2021-01-27 | Loyola-Chicago | Southern Illinois | Cancelled | - | - | ||
| 30 | 2021-01-30 | Valparaiso | Loyola-Chicago | Cancelled | - | - | ||
| 31 | 2021-01-31 | Loyola-Chicago (263) | 72 | 46 | Missouri State (224) | Final | W | 26 |
| 32 | 2021-02-01 | Loyola-Chicago (263) | 70 | 50 | Missouri State (224) | Final | W | 20 |
| 33 | 2021-02-03 | Evansville | Loyola-Chicago | Cancelled | - | - | ||
| 34 | 2021-02-06 | Loyola-Chicago | Northern Iowa | Cancelled | - | - | ||
| 35 | 2021-02-06 | Evansville (302) | 55 | 68 | Loyola-Chicago (263) | Final | W | 13 |
| 36 | 2021-02-07 | Evansville (302) | 58 | 69 | Loyola-Chicago (263) | Final | W | 11 |
| 37 | 2021-02-09 | Southern Illinois | Loyola-Chicago | Cancelled | - | - | ||
| 38 | 2021-02-13 | Loyola-Chicago | Bradley | Cancelled | - | - | ||
| 39 | 2021-02-13 | Loyola-Chicago | 0 | 0 | Indiana State | Cancelled | - | - |
| 40 | 2021-02-13 | Loyola-Chicago (263) | 81 | 54 | Drake (217) | Final | W | 27 |
| 41 | 2021-02-14 | Loyola-Chicago | 0 | 0 | Indiana State | Cancelled | - | - |
| 42 | 2021-02-14 | Loyola-Chicago (263) | 50 | 51 | Drake (217) | Final/OT | L | -1 |
| 43 | 2021-02-16 | Loyola-Chicago | Illinois State | Cancelled | - | - | ||
| 44 | 2021-02-17 | Valparaiso (156) | 52 | 54 | Loyola-Chicago (263) | Final | W | 2 |
| 45 | 2021-02-20 | Indiana State | Loyola-Chicago | Cancelled | - | - | ||
| 46 | 2021-02-24 | Loyola-Chicago | Drake | Cancelled | - | - | ||
| 47 | 2021-02-26 | Southern Illinois (150) | 52 | 60 | Loyola-Chicago (263) | Final | W | 8 |
| 48 | 2021-02-27 | Northern Iowa | Loyola-Chicago | Cancelled | - | - | ||
| 49 | 2021-02-27 | Southern Illinois (150) | 58 | 65 | Loyola-Chicago (263) | Final/OT | W | 7 |
| 50 | 2021-03-05 | Southern Illinois (150) | 49 | 73 | Loyola-Chicago (263) | Final | W | 24 |
| 51 | 2021-03-06 | Indiana State (243) | 49 | 65 | Loyola-Chicago (263) | Final | W | 16 |
| 52 | 2021-03-07 | Drake (217) | 65 | 75 | Loyola-Chicago (263) | Final | W | 10 |
| 53 | 2021-03-19 | Georgia Tech (36) | 60 | 71 | Loyola-Chicago (27) | Final | W | 11 |
| 54 | 2021-03-21 | Loyola-Chicago (27) | 71 | 58 | Illinois (3) | Final | W | 13 |
| 55 | 2021-03-27 | Oregon State (69) | 65 | 58 | Loyola-Chicago (27) | Final | L | -7 |