Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Evangel | 0 | 0 | Missouri State (224) | Cancelled | - | - |
| 2 | 2020-11-28 | Ecclesia | 0 | 0 | Missouri State (224) | Cancelled | - | - |
| 3 | 2020-11-28 | Ecclesia | Missouri State (148) | Cancelled | - | - | ||
| 4 | 2020-12-01 | Central Arkansas (143) | 0 | 0 | Missouri State (224) | Cancelled | - | - |
| 5 | 2020-12-01 | Central Arkansas (148) | Missouri State (191) | Cancelled | - | - | ||
| 6 | 2020-12-05 | Mississippi Valley State (365) | 0 | 0 | Missouri State (224) | Cancelled | - | - |
| 7 | 2020-12-05 | Mississippi Valley State (355) | Missouri State (191) | Cancelled | - | - | ||
| 8 | 2020-12-12 | Southeastern Louisiana (318) | 0 | 0 | Missouri State (224) | Cancelled | - | - |
| 9 | 2020-12-12 | Southeastern Louisiana (315) | Missouri State (189) | Cancelled | - | - | ||
| 10 | 2020-12-16 | William Jewell | 64 | 73 | Missouri State (224) | Final | W | 9 |
| 11 | 2020-12-19 | Northwestern State (315) | 67 | 94 | Missouri State (224) | Final | W | 27 |
| 12 | 2020-12-21 | Little Rock (321) | 77 | 85 | Missouri State (224) | Final | W | 8 |
| 13 | 2020-12-27 | Missouri State (224) | 79 | 59 | Northern Iowa (89) | Final | W | 20 |
| 14 | 2020-12-28 | Missouri State (224) | 75 | 85 | Northern Iowa (89) | Final | L | -10 |
| 15 | 2021-01-02 | Evansville (283) | Missouri State (64) | Cancelled | - | - | ||
| 16 | 2021-01-02 | Indiana State (243) | 74 | 84 | Missouri State (224) | Final | W | 10 |
| 17 | 2021-01-03 | Indiana State (243) | 66 | 70 | Missouri State (224) | Final | W | 4 |
| 18 | 2021-01-07 | Loyola-Chicago (76) | Missouri State (92) | Cancelled | - | - | ||
| 19 | 2021-01-09 | Missouri State (224) | 81 | 68 | Valparaiso (156) | Final | W | 13 |
| 20 | 2021-01-10 | Missouri State (224) | 78 | 68 | Valparaiso (156) | Final | W | 10 |
| 21 | 2021-01-13 | Southern Illinois | Missouri State | Cancelled | - | - | ||
| 22 | 2021-01-16 | Missouri State | Valparaiso | Cancelled | - | - | ||
| 23 | 2021-01-17 | Missouri S&T | 49 | 94 | Missouri State (224) | Final | W | 45 |
| 24 | 2021-01-17 | Drake (217) | 0 | 0 | Missouri State (224) | Postponed | - | - |
| 25 | 2021-01-18 | Drake (11) | 0 | 0 | Missouri State (71) | Cancelled | - | - |
| 26 | 2021-01-19 | Missouri State | Loyola-Chicago | Cancelled | - | - | ||
| 27 | 2021-01-23 | Illinois State | Missouri State | Cancelled | - | - | ||
| 28 | 2021-01-26 | Drake (217) | 68 | 61 | Missouri State (224) | Final | L | -7 |
| 29 | 2021-01-27 | Northern Iowa | Missouri State | Cancelled | - | - | ||
| 30 | 2021-01-27 | Drake (217) | 78 | 73 | Missouri State (224) | Final | L | -5 |
| 31 | 2021-01-31 | Missouri State | Indiana State | Cancelled | - | - | ||
| 32 | 2021-01-31 | Loyola-Chicago (263) | 72 | 46 | Missouri State (224) | Final | L | -26 |
| 33 | 2021-02-01 | Loyola-Chicago (263) | 70 | 50 | Missouri State (224) | Final | L | -20 |
| 34 | 2021-02-03 | Missouri State | Bradley | Cancelled | - | - | ||
| 35 | 2021-02-06 | Drake | Missouri State | Cancelled | - | - | ||
| 36 | 2021-02-06 | Missouri State (224) | 74 | 67 | Illinois State (94) | Final | W | 7 |
| 37 | 2021-02-07 | Missouri State (224) | 72 | 62 | Illinois State (94) | Final | W | 10 |
| 38 | 2021-02-10 | Southern Illinois (150) | 53 | 65 | Missouri State (224) | Final | W | 12 |
| 39 | 2021-02-13 | Valparaiso | Missouri State | Cancelled | - | - | ||
| 40 | 2021-02-13 | Bradley (113) | 58 | 80 | Missouri State (224) | Final | W | 22 |
| 41 | 2021-02-14 | Bradley (113) | 57 | 72 | Missouri State (224) | Final | W | 15 |
| 42 | 2021-02-17 | Indiana State | Missouri State | Cancelled | - | - | ||
| 43 | 2021-02-17 | Missouri State (224) | 68 | 53 | Southern Illinois (150) | Final | W | 15 |
| 44 | 2021-02-20 | Missouri State | Evansville | Cancelled | - | - | ||
| 45 | 2021-02-24 | Bradley | Missouri State | Cancelled | - | - | ||
| 46 | 2021-02-26 | Missouri State (224) | 90 | 81 | Evansville (302) | Final | W | 9 |
| 47 | 2021-02-27 | Missouri State | Southern Illinois | Cancelled | - | - | ||
| 48 | 2021-02-27 | Missouri State (224) | 63 | 72 | Evansville (302) | Final | L | -9 |
| 49 | 2021-03-05 | Valparaiso (156) | 55 | 66 | Missouri State (224) | Final | W | 11 |
| 50 | 2021-03-06 | Missouri State (224) | 69 | 71 | Drake (217) | Final | L | -2 |