Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Mississippi Valley State (365) | 44 | 83 | Iowa State (7) | Final | W | 39 |
| 2 | 2024-11-11 | UMKC (195) | 56 | 82 | Iowa State (19) | Final | W | 26 |
| 3 | 2024-11-18 | IU-Indy (312) | 52 | 87 | Iowa State (39) | Final | W | 35 |
| 4 | 2024-11-25 | Auburn (6) | 83 | 81 | Iowa State (80) | Final | L | -2 |
| 5 | 2024-11-26 | Iowa State (47) | 89 | 84 | Dayton (89) | Final | W | 5 |
| 6 | 2024-11-27 | Colorado (83) | 71 | 99 | Iowa State (18) | Final | W | 28 |
| 7 | 2024-12-04 | Marquette (6) | 70 | 81 | Iowa State (7) | Final | W | 11 |
| 8 | 2024-12-08 | Jackson State (348) | 58 | 100 | Iowa State (8) | Final | W | 42 |
| 9 | 2024-12-12 | Iowa State (5) | 89 | 80 | Iowa (47) | Final | W | 9 |
| 10 | 2024-12-15 | Nebraska-Omaha (317) | 51 | 83 | Iowa State (4) | Final | W | 32 |
| 11 | 2024-12-22 | Morgan State (342) | 72 | 99 | Iowa State (4) | Final | W | 27 |
| 12 | 2024-12-30 | Iowa State (4) | 79 | 69 | Colorado (60) | Final | W | 10 |
| 13 | 2025-01-04 | Baylor (39) | 55 | 74 | Iowa State (3) | Final | W | 19 |
| 14 | 2025-01-07 | Utah (94) | 59 | 82 | Iowa State (2) | Final | W | 23 |
| 15 | 2025-01-11 | Iowa State (2) | 85 | 84 | Texas Tech (38) | Final (OT) | W | 1 |
| 16 | 2025-01-15 | Kansas (10) | 57 | 74 | Iowa State (3) | Final | W | 17 |
| 17 | 2025-01-18 | Iowa State (3) | 57 | 64 | West Virginia (25) | Final | L | -7 |
| 18 | 2025-01-21 | Central Florida (53) | 83 | 108 | Iowa State (4) | Final | W | 25 |
| 19 | 2025-01-25 | Iowa State (3) | 76 | 61 | Arizona State (59) | Final | W | 15 |
| 20 | 2025-01-27 | Iowa State (3) | 75 | 86 | Arizona (29) | Final (OT) | L | -11 |
| 21 | 2025-02-01 | Kansas State (85) | 80 | 61 | Iowa State (9) | Final | L | -19 |
| 22 | 2025-02-03 | Iowa State (13) | 52 | 69 | Kansas (11) | Final | L | -17 |
| 23 | 2025-02-08 | TCU (70) | 52 | 82 | Iowa State (12) | Final | W | 30 |
| 24 | 2025-02-11 | Iowa State (12) | 77 | 65 | Central Florida (65) | Final | W | 12 |
| 25 | 2025-02-15 | Cincinnati (60) | 70 | 81 | Iowa State (10) | Final | W | 11 |
| 26 | 2025-02-18 | Colorado (106) | 65 | 79 | Iowa State (11) | Final | W | 14 |
| 27 | 2025-02-22 | Iowa State (11) | 59 | 68 | Houston (6) | Final | L | -9 |
| 28 | 2025-02-25 | Iowa State (7) | 68 | 74 | Oklahoma State (57) | Final | L | -6 |
| 29 | 2025-03-01 | Arizona (2) | 67 | 84 | Iowa State (7) | Final | W | 17 |
| 30 | 2025-03-04 | BYU (32) | 88 | 85 | Iowa State (21) | Final (2OT) | L | -3 |
| 31 | 2025-03-08 | Iowa State (18) | 73 | 57 | Kansas State (78) | Final | W | 16 |
| 32 | 2025-03-12 | Cincinnati (59) | 56 | 76 | Iowa State (15) | Final | W | 20 |
| 33 | 2025-03-13 | Iowa State (15) | 92 | 96 | BYU (30) | Final | L | -4 |
| 34 | 2025-03-21 | Lipscomb (102) | 55 | 82 | Iowa State (19) | Final | W | 27 |
| 35 | 2025-03-23 | Ole Miss (16) | 91 | 78 | Iowa State (19) | Final | L | -13 |