Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Jackson State (129) | 40 | 97 | Houston (114) | Final | W | 57 |
| 2 | 2024-11-09 | Auburn (2) | 74 | 69 | Houston (118) | Final | L | -5 |
| 3 | 2024-11-13 | Louisiana (339) | 45 | 91 | Houston (79) | Final | W | 46 |
| 4 | 2024-11-22 | Hofstra (148) | 44 | 80 | Houston (46) | Final | W | 36 |
| 5 | 2024-11-26 | Alabama (14) | 85 | 80 | Houston (70) | Final (OT) | L | -5 |
| 6 | 2024-11-28 | Houston (41) | 65 | 54 | Notre Dame (115) | Final | W | 11 |
| 7 | 2024-11-30 | San Diego State (48) | 73 | 70 | Houston (68) | Final (OT) | L | -3 |
| 8 | 2024-12-07 | Butler (53) | 51 | 79 | Houston (35) | Final | W | 28 |
| 9 | 2024-12-10 | Troy (138) | 42 | 62 | Houston (37) | Final | W | 20 |
| 10 | 2024-12-18 | Toledo (185) | 49 | 78 | Houston (29) | Final | W | 29 |
| 11 | 2024-12-21 | Texas A&M-Corpus Christi (207) | 51 | 87 | Houston (25) | Final | W | 36 |
| 12 | 2024-12-30 | Houston (25) | 60 | 47 | Oklahoma State (112) | Final | W | 13 |
| 13 | 2025-01-04 | BYU (57) | 55 | 86 | Houston (19) | Final | W | 31 |
| 14 | 2025-01-06 | TCU (86) | 46 | 65 | Houston (18) | Final | W | 19 |
| 15 | 2025-01-11 | Houston (17) | 87 | 57 | Kansas State (128) | Final | W | 30 |
| 16 | 2025-01-15 | West Virginia (26) | 54 | 70 | Houston (17) | Final | W | 16 |
| 17 | 2025-01-18 | Houston (7) | 69 | 68 | Central Florida (50) | Final | W | 1 |
| 18 | 2025-01-22 | Utah (77) | 36 | 70 | Houston (7) | Final | W | 34 |
| 19 | 2025-01-25 | Houston (7) | 92 | 86 | Kansas (11) | Final (2OT) | W | 6 |
| 20 | 2025-01-29 | Houston (4) | 63 | 49 | West Virginia (39) | Final | W | 14 |
| 21 | 2025-02-01 | Texas Tech (17) | 82 | 81 | Houston (5) | Final (OT) | L | -1 |
| 22 | 2025-02-04 | Oklahoma State (107) | 63 | 72 | Houston (6) | Final | W | 9 |
| 23 | 2025-02-08 | Houston (6) | 69 | 59 | Colorado (117) | Final | W | 10 |
| 24 | 2025-02-10 | Baylor (38) | 65 | 76 | Houston (6) | Final | W | 11 |
| 25 | 2025-02-15 | Houston (6) | 62 | 58 | Arizona (23) | Final | W | 4 |
| 26 | 2025-02-18 | Houston (6) | 80 | 65 | Arizona State (75) | Final | W | 15 |
| 27 | 2025-02-22 | Iowa State (11) | 59 | 68 | Houston (6) | Final | W | 9 |
| 28 | 2025-02-24 | Houston (4) | 69 | 61 | Texas Tech (18) | Final | W | 8 |
| 29 | 2025-03-01 | Cincinnati (55) | 64 | 73 | Houston (5) | Final | W | 9 |
| 30 | 2025-03-03 | Kansas (31) | 59 | 65 | Houston (5) | Final | W | 6 |
| 31 | 2025-03-08 | Houston (4) | 65 | 61 | Baylor (43) | Final | W | 4 |
| 32 | 2025-03-13 | Colorado (87) | 68 | 77 | Houston (4) | Final | W | 9 |
| 33 | 2025-03-14 | BYU (27) | 54 | 74 | Houston (4) | Final | W | 20 |
| 34 | 2025-03-15 | Arizona | 64 | 72 | Houston | Final | W | 8 |
| 35 | 2025-03-20 | SIU-Edwardsville (197) | 40 | 78 | Houston (4) | Final | W | 38 |
| 36 | 2025-03-22 | Gonzaga (22) | 76 | 81 | Houston (4) | Final | W | 5 |
| 37 | 2025-03-28 | Purdue (20) | 60 | 62 | Houston (4) | Final | W | 2 |
| 38 | 2025-03-30 | Tennessee (5) | 50 | 69 | Houston (4) | Final | W | 19 |
| 39 | 2025-04-05 | Houston (4) | 70 | 67 | Duke (3) | Final | W | 3 |
| 40 | 2025-04-07 | Florida (2) | 65 | 63 | Houston (4) | Final | L | -2 |