NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Canisius (320) | 42 | 102 | Buffalo (101) | Final | L | -60 |
| 2 | 2021-11-13 | Canisius (320) | 56 | 73 | Binghamton (279) | Final | L | -17 |
| 3 | 2021-11-17 | Canisius (332) | 59 | 67 | St. Bonaventure (139) | Final | L | -8 |
| 4 | 2021-11-20 | Colgate (224) | 58 | 61 | Canisius (332) | Final | W | 3 |
| 5 | 2021-11-23 | Detroit (320) | 55 | 64 | Canisius (347) | Final | W | 9 |
| 6 | 2021-11-27 | Robert Morris (279) | 57 | 43 | Canisius (312) | Final | L | -14 |
| 7 | 2021-12-01 | Canisius (312) | 60 | 69 | Duquesne (191) | Final | L | -9 |
| 8 | 2021-12-08 | Youngstown State (68) | 69 | 66 | Canisius (326) | Final | L | -3 |
| 9 | 2021-12-15 | Canisius (333) | 46 | 65 | Albany (227) | Final | L | -19 |
| 10 | 2021-12-19 | Saint Peter's (340) | 65 | 55 | Canisius (347) | Final | L | -10 |
| 11 | 2021-12-21 | Manhattan (189) | 85 | 63 | Canisius (338) | Final | L | -22 |
| 12 | 2021-12-30 | Canisius (341) | 0 | 0 | Marist (237) | Postponed | - | - |
| 13 | 2022-01-01 | Canisius (341) | 0 | 0 | Quinnipiac (143) | Postponed | - | - |
| 14 | 2022-01-09 | Niagara (362) | 87 | 86 | Canisius (347) | Final/OT | L | -1 |
| 15 | 2022-01-13 | Rider (339) | 59 | 51 | Canisius (347) | Final | L | -8 |
| 16 | 2022-01-15 | Fairfield (133) | 73 | 37 | Canisius (336) | Final | L | -36 |
| 17 | 2022-01-20 | Canisius (339) | 55 | 74 | Saint Peter's (265) | Final | L | -19 |
| 18 | 2022-01-22 | Canisius (339) | 48 | 60 | Monmouth (185) | Final | L | -12 |
| 19 | 2022-01-24 | Canisius (339) | 44 | 57 | Marist (259) | Final | L | -13 |
| 20 | 2022-01-27 | Quinnipiac (99) | 62 | 53 | Canisius (347) | Final | L | -9 |
| 21 | 2022-01-29 | Siena (292) | 78 | 81 | Canisius (343) | Final | W | 3 |
| 22 | 2022-02-03 | Canisius (336) | 55 | 66 | Iona (272) | Final | L | -11 |
| 23 | 2022-02-05 | Canisius (347) | 54 | 63 | Fairfield (50) | Final/OT | L | -9 |
| 24 | 2022-02-07 | Canisius (347) | 55 | 76 | Quinnipiac (99) | Final | L | -21 |
| 25 | 2022-02-10 | Monmouth (185) | 62 | 52 | Canisius (347) | Final | L | -10 |
| 26 | 2022-02-12 | Marist (283) | 61 | 65 | Canisius (337) | Final | W | 4 |
| 27 | 2022-02-17 | Canisius (336) | 62 | 86 | Manhattan (186) | Final | L | -24 |
| 28 | 2022-02-19 | Canisius (336) | 57 | 71 | Rider (295) | Final | L | -14 |
| 29 | 2022-02-24 | Canisius (337) | 54 | 56 | Siena (296) | Final | L | -2 |
| 30 | 2022-02-26 | Canisius (337) | 78 | 82 | Niagara (254) | Final | L | -4 |
| 31 | 2022-03-05 | Iona (262) | 62 | 71 | Canisius (336) | Final | W | 9 |
| 32 | 2022-03-08 | Canisius (331) | 71 | 65 | Monmouth (257) | Final | W | 6 |
| 33 | 2022-03-10 | Canisius (331) | 49 | 61 | Manhattan (175) | Final | L | -12 |