NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | McNeese State (331) | 65 | 60 | Arkansas-Pine Bluff (325) | Final | W | 5 |
| 2 | 2021-11-13 | Southwest Assemblies of God | 48 | 98 | McNeese State (331) | Final | W | 50 |
| 3 | 2021-11-15 | McNeese State (331) | 72 | 96 | Arkansas State (257) | Final | L | -24 |
| 4 | 2021-11-21 | McNeese State (215) | 70 | 74 | UTRGV (300) | Final | L | -4 |
| 5 | 2021-11-23 | Champion Christian | McNeese State | Cancelled | - | - | ||
| 6 | 2021-11-24 | Centenary | 53 | 91 | McNeese State (265) | Final | W | 38 |
| 7 | 2021-11-28 | Louisiana (175) | 67 | 57 | McNeese State (265) | Final | L | -10 |
| 8 | 2021-12-01 | McNeese State (274) | 55 | 102 | Mississippi State (50) | Final | L | -47 |
| 9 | 2021-12-07 | McNeese State (281) | 76 | 88 | Lamar (274) | Final | L | -12 |
| 10 | 2021-12-11 | McNeese State (281) | 60 | 102 | California (83) | Final | L | -42 |
| 11 | 2021-12-13 | McNeese State (281) | 38 | 109 | Oregon (63) | Final | L | -71 |
| 12 | 2021-12-22 | Louisiana Tech (151) | 74 | 57 | McNeese State (299) | Final | L | -17 |
| 13 | 2022-01-03 | McNeese State (301) | 0 | 0 | Southeastern Louisiana (262) | Canceled | - | - |
| 14 | 2022-01-15 | Houston Baptist (320) | 82 | 74 | McNeese State (300) | Final | L | -8 |
| 15 | 2022-01-20 | McNeese State (303) | 61 | 72 | Texas A&M-Corpus Christi (231) | Final | L | -11 |
| 16 | 2022-01-22 | McNeese State (303) | 67 | 57 | Incarnate Word (307) | Final | W | 10 |
| 17 | 2022-01-29 | New Orleans (350) | 61 | 72 | McNeese State (303) | Final | W | 11 |
| 18 | 2022-02-03 | Southeastern Louisiana (207) | 69 | 68 | McNeese State (295) | Final | L | -1 |
| 19 | 2022-02-12 | McNeese State (290) | 72 | 90 | Northwestern State (312) | Final | L | -18 |
| 20 | 2022-02-17 | McNeese State (300) | 63 | 53 | Nicholls State (338) | Final | W | 10 |
| 21 | 2022-02-19 | McNeese State (300) | 75 | 64 | New Orleans (347) | Final | W | 11 |
| 22 | 2022-02-24 | Texas A&M-Corpus Christi (207) | 65 | 76 | McNeese State (298) | Final | W | 11 |
| 23 | 2022-02-26 | Incarnate Word (316) | 65 | 73 | McNeese State (298) | Final | W | 8 |
| 24 | 2022-03-05 | McNeese State (288) | 61 | 68 | Houston Baptist (260) | Final | L | -7 |
| 25 | 2022-03-11 | Incarnate Word (319) | 90 | 63 | McNeese State (289) | Final | L | -27 |