Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Gardner-Webb | 25 | Georgia Southern | 30 | Final | L | -5 |
| 2 | 2021-09-11 | Gardner-Webb | 10 | Charlotte | 38 | Final | L | -28 |
| 3 | 2021-09-18 | Lincoln (PA) | 0 | Gardner-Webb | 56 | Final | W | 56 |
| 4 | 2021-09-25 | Western Carolina | 34 | Gardner-Webb | 52 | Final | W | 18 |
| 5 | 2021-10-02 | Gardner-Webb | 17 | Monmouth | 54 | Final | L | -37 |
| 6 | 2021-10-09 | Campbell | 42 | Gardner-Webb | 28 | Final | L | -14 |
| 7 | 2021-10-23 | Robert Morris | 17 | Gardner-Webb | 28 | Final | W | 11 |
| 8 | 2021-10-30 | Gardner-Webb | 30 | Kennesaw State | 34 | Final | L | -4 |
| 9 | 2021-11-06 | Gardner-Webb | 21 | Hampton | 27 | Final(OT) | L | -6 |
| 10 | 2021-11-13 | Charleston Southern | 32 | Gardner-Webb | 24 | Final(OT) | L | -8 |
| 11 | 2021-11-20 | Gardner-Webb | 35 | North Carolina A&T | 27 | Final | W | 8 |