Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | North Dakota | 35 | Idaho State | 14 | Final | W | 21 |
| 2 | 2021-09-10 | North Dakota | 24 | Utah State | 48 | Final | L | -24 |
| 3 | 2021-09-18 | Drake | 0 | North Dakota | 38 | Final | W | 38 |
| 4 | 2021-10-02 | North Dakota State | 16 | North Dakota | 10 | Final | L | -6 |
| 5 | 2021-10-09 | North Dakota | 13 | South Dakota | 20 | Final | L | -7 |
| 6 | 2021-10-16 | North Dakota | 28 | Southern Illinois | 31 | Final | L | -3 |
| 7 | 2021-10-23 | Western Illinois | 10 | North Dakota | 34 | Final | W | 24 |
| 8 | 2021-10-23 | Towson | 10 | North Dakota | 34 | Final | W | 24 |
| 9 | 2021-10-30 | North Dakota | 28 | Missouri State | 32 | Final | L | -4 |
| 10 | 2021-11-06 | Youngstown State | 21 | North Dakota | 24 | Final | W | 3 |
| 11 | 2021-11-13 | Illinois State | 7 | North Dakota | 14 | Final | W | 7 |
| 12 | 2021-11-20 | North Dakota | 21 | South Dakota State | 24 | Final | L | -3 |