Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Tennessee-Martin | 21 | Western Kentucky | 59 | Final | W | 38 |
| 2 | 2021-09-11 | Western Kentucky | 35 | Army | 38 | Final | L | -3 |
| 3 | 2021-09-25 | Indiana | 33 | Western Kentucky | 31 | Final | L | -2 |
| 4 | 2021-10-02 | Western Kentucky | 31 | Michigan State | 48 | Final | L | -17 |
| 5 | 2021-10-06 | UTSA | 0 | Western Kentucky | 0 | Cancelled | - | - |
| 6 | 2021-10-09 | UTSA | 52 | Western Kentucky | 46 | Final | L | -6 |
| 7 | 2021-10-16 | Western Kentucky | 43 | Old Dominion | 20 | Final | W | 23 |
| 8 | 2021-10-23 | Western Kentucky | 34 | Florida International | 19 | Final | W | 15 |
| 9 | 2021-10-30 | Charlotte | 13 | Western Kentucky | 45 | Final | W | 32 |
| 10 | 2021-11-06 | Middle Tennessee | 21 | Western Kentucky | 48 | Final | W | 27 |
| 11 | 2021-11-13 | Western Kentucky | 42 | Rice | 21 | Final | W | 21 |
| 12 | 2021-11-20 | Florida Atlantic | 17 | Western Kentucky | 52 | Final | W | 35 |
| 13 | 2021-11-27 | Western Kentucky (44) | 53 | Marshall (68) | 21 | Final | W | 32 |
| 14 | 2021-12-03 | Western Kentucky (47) | 41 | UTSA (18) | 49 | Final | L | -8 |
| 15 | 2021-12-18 | Western Kentucky (42) | 59 | Appalachian State (36) | 38 | Final | W | 21 |