Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | La Verne | 0 | San Diego (194) | 58 | Final | W | 58 |
| 2 | 2022-09-10 | San Diego (194) | 27 | Cal Poly (228) | 28 | Final | L | -1 |
| 3 | 2022-09-17 | San Diego (244) | 13 | UC-Davis (185) | 43 | Final | L | -30 |
| 4 | 2022-09-24 | San Diego (253) | 21 | Valparaiso (233) | 28 | Final | L | -7 |
| 5 | 2022-10-01 | Stetson (198) | 0 | San Diego (253) | 0 | Cancelled | - | - |
| 6 | 2022-10-08 | San Diego (253) | 22 | Drake (261) | 10 | Final | W | 12 |
| 7 | 2022-10-15 | Presbyterian (258) | 0 | San Diego (246) | 0 | Final | - | - |
| 8 | 2022-10-29 | San Diego (257) | 42 | St. Thomas (189) | 49 | Final | L | -7 |
| 9 | 2022-11-05 | Butler (183) | 26 | San Diego (256) | 23 | Final | L | -3 |
| 10 | 2022-11-12 | Davidson (200) | 14 | San Diego (245) | 31 | Final | W | 17 |
| 11 | 2022-11-19 | San Diego (245) | 14 | Morehead State (259) | 9 | Final | W | 5 |