Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Morehead State (198) | 13 | Mercer (149) | 63 | Final | L | -50 |
| 2 | 2022-09-10 | Morehead State (198) | 13 | Montana State (96) | 63 | Final | L | -50 |
| 3 | 2022-09-17 | Kentucky Christian | 14 | Morehead State (251) | 49 | Final | W | 35 |
| 4 | 2022-09-24 | Morehead State (250) | 26 | Stetson (198) | 38 | Final | L | -12 |
| 5 | 2022-10-01 | Presbyterian (257) | 10 | Morehead State (238) | 14 | Final | W | 4 |
| 6 | 2022-10-15 | Morehead State (245) | 26 | Davidson (186) | 28 | Final | L | -2 |
| 7 | 2022-10-22 | Valparaiso (224) | 40 | Morehead State (251) | 35 | Final | L | -5 |
| 8 | 2022-10-29 | Morehead State (255) | 20 | Butler (184) | 56 | Final | L | -36 |
| 9 | 2022-11-05 | Marist (239) | 31 | Morehead State (257) | 21 | Final | L | -10 |
| 10 | 2022-11-12 | Morehead State (258) | 27 | Dayton (199) | 49 | Final | L | -22 |
| 11 | 2022-11-19 | San Diego (245) | 14 | Morehead State (259) | 9 | Final | L | -5 |