Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Drake (248) | 14 | North Dakota State (54) | 56 | Final | L | -42 |
| 2 | 2022-09-03 | Drake (248) | 14 | North Dakota State (54) | 56 | Final | L | -42 |
| 3 | 2022-09-10 | Missouri S&T | 17 | Drake (248) | 14 | Final(OT) | L | -3 |
| 4 | 2022-09-17 | Drake (261) | 14 | Idaho (183) | 42 | Final | L | -28 |
| 5 | 2022-09-24 | Marist (252) | 30 | Drake (261) | 25 | Final | L | -5 |
| 6 | 2022-10-01 | Drake (261) | 14 | Dayton (203) | 27 | Final | L | -13 |
| 7 | 2022-10-08 | San Diego (253) | 22 | Drake (261) | 10 | Final | L | -12 |
| 8 | 2022-10-15 | Drake (261) | 14 | St. Thomas (191) | 26 | Final | L | -12 |
| 9 | 2022-10-22 | Davidson (185) | 48 | Drake (261) | 14 | Final | L | -34 |
| 10 | 2022-10-29 | Drake (259) | 24 | Stetson (254) | 17 | Final | W | 7 |
| 11 | 2022-11-12 | Butler (201) | 24 | Drake (255) | 27 | Final | W | 3 |
| 12 | 2022-11-19 | Drake (249) | 24 | Valparaiso (241) | 0 | Final | W | 24 |