Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Mars Hill | 7 | East Tennessee State (111) | 44 | Final | W | 37 |
| 2 | 2022-09-10 | East Tennessee State (111) | 17 | The Citadel (217) | 20 | Final | L | -3 |
| 3 | 2022-09-17 | Furman (170) | 27 | East Tennessee State (247) | 14 | Final | L | -13 |
| 4 | 2022-09-24 | East Tennessee State (213) | 45 | Robert Morris (251) | 3 | Final | W | 42 |
| 5 | 2022-10-01 | Chattanooga (152) | 24 | East Tennessee State (220) | 16 | Final | L | -8 |
| 6 | 2022-10-08 | East Tennessee State (206) | 44 | Virginia Military (236) | 21 | Final | W | 23 |
| 7 | 2022-10-15 | East Tennessee State (212) | 33 | Mercer (129) | 55 | Final | L | -22 |
| 8 | 2022-10-22 | Samford (139) | 55 | East Tennessee State (214) | 45 | Final | L | -10 |
| 9 | 2022-10-29 | East Tennessee State (223) | 41 | Wofford (208) | 48 | Final | L | -7 |
| 10 | 2022-11-12 | Western Carolina (195) | 20 | East Tennessee State (224) | 17 | Final | L | -3 |
| 11 | 2022-11-19 | East Tennessee State (224) | 7 | Mississippi State (21) | 56 | Final | L | -49 |