Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Wofford (238) | 0 | Chattanooga (159) | 31 | Final | L | -31 |
| 2 | 2022-09-10 | Elon (167) | 26 | Wofford (238) | 0 | Final | L | -26 |
| 3 | 2022-09-17 | Wofford (236) | 7 | Virginia Tech (81) | 27 | Final | L | -20 |
| 4 | 2022-09-24 | Wofford (244) | 22 | Kennesaw State (203) | 24 | Final | L | -2 |
| 5 | 2022-10-01 | Mercer (142) | 42 | Wofford (244) | 7 | Final | L | -35 |
| 6 | 2022-10-08 | Wofford (235) | 14 | Samford (142) | 28 | Final | L | -14 |
| 7 | 2022-10-15 | The Citadel (222) | 16 | Wofford (221) | 31 | Final | W | 15 |
| 8 | 2022-10-29 | East Tennessee State (223) | 41 | Wofford (208) | 48 | Final | W | 7 |
| 9 | 2022-11-05 | Wofford (217) | 29 | Western Carolina (200) | 36 | Final | L | -7 |
| 10 | 2022-11-12 | Virginia Military (246) | 16 | Wofford (206) | 34 | Final | W | 18 |
| 11 | 2022-11-19 | Wofford (214) | 28 | Furman (135) | 63 | Final | L | -35 |