Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Morehead State (198) | 13 | Mercer (149) | 63 | Final | W | 50 |
| 2 | 2022-09-03 | Mercer (149) | 16 | Auburn (43) | 42 | Final | L | -26 |
| 3 | 2022-09-17 | The Citadel (217) | 0 | Mercer (153) | 17 | Final | W | 17 |
| 4 | 2022-09-24 | Mercer (148) | 45 | Gardner-Webb (215) | 14 | Final | W | 31 |
| 5 | 2022-10-01 | Mercer (142) | 42 | Wofford (244) | 7 | Final | W | 35 |
| 6 | 2022-10-08 | Western Carolina (186) | 6 | Mercer (128) | 49 | Final | W | 43 |
| 7 | 2022-10-15 | East Tennessee State (212) | 33 | Mercer (129) | 55 | Final | W | 22 |
| 8 | 2022-10-22 | Mercer (141) | 21 | Chattanooga (137) | 41 | Final | L | -20 |
| 9 | 2022-10-29 | Mercer (142) | 55 | Virginia Military (242) | 14 | Final | W | 41 |
| 10 | 2022-11-12 | Furman (139) | 23 | Mercer (150) | 13 | Final | L | -10 |
| 11 | 2022-11-19 | Mercer (153) | 44 | Samford (124) | 50 | Final(OT) | L | -6 |