Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Western Michigan (61) | 13 | Michigan State (10) | 35 | Final | L | -22 |
| 2 | 2022-09-10 | Western Michigan (61) | 37 | Ball State (91) | 30 | Final | W | 7 |
| 3 | 2022-09-17 | Pittsburgh (37) | 34 | Western Michigan (88) | 13 | Final | L | -21 |
| 4 | 2022-09-24 | Western Michigan (110) | 6 | San Jose State (70) | 34 | Final | L | -28 |
| 5 | 2022-10-01 | New Hampshire (165) | 7 | Western Michigan (106) | 44 | Final | W | 37 |
| 6 | 2022-10-08 | Eastern Michigan (111) | 45 | Western Michigan (120) | 23 | Final | L | -22 |
| 7 | 2022-10-15 | Ohio (96) | 33 | Western Michigan (128) | 14 | Final | L | -19 |
| 8 | 2022-10-22 | Western Michigan (119) | 16 | Miami (OH) (115) | 10 | Final | W | 6 |
| 9 | 2022-11-02 | Western Michigan (121) | 9 | Bowling Green (94) | 13 | Final | L | -4 |
| 10 | 2022-11-09 | Northern Illinois (126) | 24 | Western Michigan (130) | 21 | Final | L | -3 |
| 11 | 2022-11-16 | Western Michigan (125) | 12 | Central Michigan (115) | 10 | Final | W | 2 |
| 12 | 2022-11-25 | Toledo (84) | 14 | Western Michigan (118) | 20 | Final | W | 6 |