Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Long Island | 0 | Toledo (84) | 37 | Final | W | 37 |
| 2 | 2022-09-10 | Massachusetts (206) | 10 | Toledo (84) | 55 | Final | W | 45 |
| 3 | 2022-09-17 | Toledo (57) | 21 | Ohio State (1) | 77 | Final | L | -56 |
| 4 | 2022-09-24 | Toledo (88) | 14 | San Diego State (95) | 17 | Final | L | -3 |
| 5 | 2022-10-01 | Central Michigan (111) | 17 | Toledo (74) | 38 | Final | W | 21 |
| 6 | 2022-10-08 | Toledo (64) | 52 | Northern Illinois (140) | 32 | Final | W | 20 |
| 7 | 2022-10-15 | Kent State (105) | 31 | Toledo (51) | 52 | Final | W | 21 |
| 8 | 2022-10-22 | Toledo (70) | 27 | Buffalo (71) | 34 | Final | L | -7 |
| 9 | 2022-10-29 | Toledo (64) | 27 | Eastern Michigan (116) | 24 | Final | W | 3 |
| 10 | 2022-11-08 | Ball State (95) | 21 | Toledo (59) | 28 | Final | W | 7 |
| 11 | 2022-11-15 | Bowling Green (100) | 42 | Toledo (72) | 35 | Final | L | -7 |
| 12 | 2022-11-25 | Toledo (84) | 14 | Western Michigan (118) | 20 | Final | L | -6 |
| 13 | 2022-12-03 | Toledo (74) | 17 | Ohio (70) | 7 | Final | W | 10 |
| 14 | 2022-12-20 | Liberty (73) | 19 | Toledo (74) | 21 | Final | W | 2 |