Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Wyoming (81) | 6 | Illinois (65) | 38 | Final | L | -32 |
| 2 | 2022-09-03 | Tulsa (71) | 37 | Wyoming (81) | 40 | Final | W | 3 |
| 3 | 2022-09-10 | Northern Colorado (221) | 10 | Wyoming (81) | 33 | Final | W | 23 |
| 4 | 2022-09-16 | Air Force (69) | 14 | Wyoming (44) | 17 | Final | W | 3 |
| 5 | 2022-09-24 | Wyoming (64) | 24 | BYU (21) | 38 | Final | L | -14 |
| 6 | 2022-10-01 | San Jose State (51) | 33 | Wyoming (75) | 16 | Final | L | -17 |
| 7 | 2022-10-08 | Wyoming (68) | 27 | New Mexico (112) | 14 | Final | W | 13 |
| 8 | 2022-10-22 | Utah State (122) | 14 | Wyoming (73) | 28 | Final | W | 14 |
| 9 | 2022-10-30 | Wyoming (73) | 27 | Hawaii (157) | 20 | Final | W | 7 |
| 10 | 2022-11-12 | Wyoming (78) | 14 | Colorado State (155) | 13 | Final | W | 1 |
| 11 | 2022-11-19 | Boise State (52) | 20 | Wyoming (80) | 17 | Final | L | -3 |
| 12 | 2022-11-25 | Wyoming (88) | 0 | Fresno State (55) | 30 | Final | L | -30 |
| 13 | 2022-12-30 | Ohio (70) | 30 | Wyoming (88) | 27 | Final(OT) | L | -3 |